MicroRNA expression profile of human advanced coronary atherosclerotic plaques
نویسندگان
چکیده
منابع مشابه
Thrombogenic potential of human coronary atherosclerotic plaques.
Higher levels of tissue factor (the initiator of blood coagulation) have been found in coronary atherosclerotic plaques of patients with unstable coronary artery disease, but it is not established whether they are associated with a different thrombotic response to in vivo plaque rupture. In 40 patients undergoing directional coronary atherectomy, prothrombin fragment 1 + 2, a marker of thrombin...
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Introduction: A number of studies have demonstrated that infectious mico organisms like helicobacter pylori may play a role in the process of atherosclerosis. We, here, aimed to investigate the effect of Helicobacter pylori DNA in atherosclerotic plaques in patients with coronary artery disease. Methods: In a cross-sectional study, 85 patients undergoing coronary artery bypass graft (CAB...
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Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix of vascular wall. Recently many studies have documented a general relationship between calcification and severity of coronary disease, and discussed the feasibility of electron beam computed tomography for detecting and quantifying the coronary artery calcification in the patients. ...
متن کاملDepletion of ATP and glucose in advanced human atherosclerotic plaques
OBJECTIVE Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaq...
متن کاملFungal rDNA signatures in coronary atherosclerotic plaques.
Bacterial DNA has been found in coronary plaques and it has therefore been concluded that bacteria may play a role as trigger factors in the chronic inflammatory process underlying coronary atherosclerosis. However, the microbial spectrum is complex and it is not known whether microorganisms other than bacteria are involved in coronary disease. Fungal 18S rDNA signatures were systematically inv...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-25690-4